讲述匹兹堡一家医院的医护人员的日常生活。

The post-apocalyptic mystery-thriller will follow a night watchman who finishes his shift at work to discover that everyone in the world who went to sleep the previous night has died. He and a band of survivors must stay awake and uncover the secret of the terrifying global epidemic before they too fall asleep.

影片是《X》《珀尔》的续集。1985年，在德州农场的血腥屠杀五年后，从成人电影界窜起、满怀抱负的女演员玛克辛（米娅·高斯 Mia Goth 饰）搬去洛杉矶，终于取得事业的重大突破。但当一名专挑好莱坞年轻艺人痛下毒手的神秘罪犯开始横行街头时，玛克辛的黑暗过去也可能将因此被揭露。